Konadu made his professional debut on May, 5 1985. In his 15th professional bout, he defeated former champion Cesar Polanco to capture the WBC International super flyweight title.
On November 7, 1989, Konadu captured the WBC and Lineal Super Flyweight Title with a decision win over two-time champion Gilberto Roman. He lost the belt in his first defense to Sung Kil Moon by technical decision. The fight was a war with both fighters exchanging knockdowns, however, the action was stopped in the ninth round due to a head butt and Moon was declared the winner on the scorecards. He lost a rematch to Moon in 1991 by knockout.
Konadu scored 15 consecutive victories over the next four years, including wins over Juan Polo Perez, former champion Victor Rabanales, and Abraham Torres. On January 28, 1996, he became a two division champion by capturing the WBA Bantamweight Title in a TKO victory over Veeraphol Sahaprom, who would go on to become a long reigning champion. He again lost the belt in his first defense to Daorung Chuvatana by technical decision, but recaptured the belt the following year in a rematch. He defended the belt once before losing it to Johnny Tapia in 1998. He rebounded with a win over former champion Hector Acero Sanchez and retired in 2001 after being TKO'd by Daniel Seda. He now lives with his family in New Dormaa, Sunyani, Ghana.